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產品關鍵詞： 香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚 茯苓新酸B 去甲異波爾定
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Abstract
Background: The dried fruit of Chaenomeles speciosa, known as Chaenomelis Fructus or Zhoupi Mugua, is a type of traditional
Chinese medicine (TCM) that is widely used to treat many diseases. Guangpi Mugua, the dried fruit of the Chaenomeles
sinensis, is its most commonly known adulterant.
Objective: To establish a robust approach for the quality control and identification of Chaenomelis Fructus.
Method: Thin-layer chromatography (TLC) was optimized and used to discriminate Chaenomelis Fructus from Guangpi
Mugua. High-performance liquid chromatography (HPLC) combined with fingerprint analysis and partial least-squares (PLS)
discrimination analysis (DA) was employed to study the chemical differences between Chaenomelis Fructus and Guangpi
Mugua. The single standard to determine multi-components (SSDMC) method, with credible precision, repeatability,
stability, and durability, was developed for quantitative analysis of the abundant markers.
Results: The developed TLC and HPLC methods were effective in the authentication of Chaenomelis Fructus. Moreover,
oleanolic acid, ursolic acid, pomolic acid, corosolic acid, 3-O-acetylpomolic acid, and one unknown compound were
identified to be critical markers for the discrimination of Chaenomelis Fructus from Guangpi Mugua.
Conclusion: Adulteration has always been a challenge in the development of TCM. This study presents useful insights that
may help solve the problem of adulteration during the preparation of Chaenomelis Fructus.
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The reference standards, tormentic acid and pomolic acid, were obtained from the Chengdu Lemeitian Pharmaceutical Technology Co., Ltd (Chengdu, China),
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