鄭重說明:

您值得信賴的中藥成分及標準合作伙伴滿足您研發和工業化需求

產品關鍵詞：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲異波爾定

guanyuwomen關于德思特

聯系方式

服務熱線：

028-8500-3950

公司傳真：	028-85589956
公司郵箱：	sales@tcmlmt.com
公司網址：	www.cbss.com.cn
公司地址：	四川省成都市溫江區海科路西段128號5棟

發表文獻展示

當前位置:首頁關于德思特 > 發表文獻展示 >

Biochemical Pharmacology-13 May 2020 黃芩素

時間：2020-09-03 瀏覽次數：分享到：

Baicalein mediates protection against Staphylococcus aureus-induced pneumonia by inhibiting the coagulase activity of vWbp

期刊名：Biochemical Pharmacology
文獻編號：DOI 10.1016/j.bcp.2020.114024
文獻地址：https://www.sciencedirect.com/science/article/abs/pii/S0006295220302513?via%3Dihub
發表日期：13 May 2020

Abstract
The emergence and spread of multidrug-resistant Staphylococcus aureus (S. aureus) necessitate the research on therapeutic tactics which are different from classical antibiotics in overcoming resistance and treating infections. In S. aureus, von Willebrand factor-binding protein (vWbp) is one of the key virulence determinants because it mediates not only the activation of thrombin to convert fibrinogen to fibrin, thereby enabling S. aureus to escape from the host immune clearance, but also the adhesion of S. aureus to host cells. Thus, vWbp is regarded as a promising druggable target to treat S. aureus-associated infections. Here we identify that baicalein, a natural compound isolated from the Chinese herb Scutellaria baicalensis, can effectively block the coagulase activity of vWbp without inhibiting the growth of the bacteria. Through thermal shift and fluorescence quenching assays, we demonstrated that baicalein directly binds to vWbp. Molecular dynamics simulations and mutagenesis assays revealed that the Asp-75 and Lys-80 residues are necessary for baicalein binding to vWbp. Importantly, we demonstrated that baicalein treatment attenuates the virulence of S. aureus and protects mice from S. aureus-induced lethal pneumonia. In addition, baicalein can improve the therapeutic effect of penicillin G by 75% in vivo. These findings indicate that baicalein might be developed as a promising therapeutic agent against drug-resistant S. aureus infections.

Baicalein was purchased from Chengdu Desite Biological Technology Co. Ltd (Wenjiang District, Chengdu, China)

上一篇：Phytomedicine-14 May 2020 香蒲新苷 α-亞麻酸紫云英苷柚皮素

下一篇：Journal of Analytical Methods in Chemistry - 13 April 2020 桉油精 α-松油

Afrormosine CAS:550-79-8 中藥對照品標準品

產品編碼：DA0040產品名稱：Afrormosine英文名:AfrormosineCAS登錄...

国产日韩高清中文无码av,久久91热狠狠色精品一区,亚洲啪AV永久无码精品放毛片,99热这里只有是精品2